For decades, endocrinology focused almost exclusively on peptides encoded by nuclear DNA. However, the discovery of Mitochondrial-Derived Peptides (MDPs) has revolutionized our understanding of cellular energy sensing. At the forefront of this new frontier in 2026 is **MOTS-c** (Mitochondrial Open Reading Frame of the 12S rRNA-c). Often referred to in the scientific community as an […]
